What is an endocannabinoid (ECS) system?

The endocannabinoid system is an internal regolator of many physiological processes taking place in our organism and is responsible for maintaining homeostasis, that is, maintaining the balance of the internal environment of the human body, external conditions. That is, at the time of the disease, the endocannabinoid system begins to produce endocannabinoids that support repair processes.

As we have written before in our cbd history article, once again we would like to remind you that it all started in the 60's in Israel then this endocannabinoid system gained the most attention. It was Dr. Raphael Mechoulam who was the first to discover in cannabis the psychoactive component of THC (tetrahydrocannabinol), and a way to isolate it from cannabis plants through extraction. Scientists began to wonder why THC is changing awareness and as a result they discovered an endocannabinoid in our body called anandamide (ananda in sanskrit means bliss).

 The isolated THC used the scientist to further understand the individual steps of the process and to draw up maps showing the location of individual cannabinoid receptors (CB1 and CB2).


The first cannabinoid receptor was discovered in 1988 and was found in the rat brain, the discovery was made by two American scientist Allyn Howlett and her PhD student William Devane. It was called cannabinoid receptor1 (CB1). Investigators have concluded that cannabinoid receptors are linked to the human brain. CB1 receptors are mainly found on neurons in the brain, spinal cord and peripheral nervous system, but are also present in other organs and tissues, including immune cells.


In 1993, another group of scientists discovered cannabinoid receptors in the immune system (CB2) and the next 2-AG endocannabinoid (2-arachidonoil glycerol) was discovered.

In addition, scientists noted that plant THC and anandamide have a very similar composition, it was recognized and found that those from plants connect to CB1 and CB2 receptors and support the work of the endocannabinoid system. Source

The endocannabinoid system is composed of :

  • cb1 and CB2 cannabinoid receptors
  • endocannabinoids produced by our body, 1.Anandamide (AEA)
  • 2-AG (2-arachidonoil glycerol)

Prevalence of CB1 cannabinoid receptors :

  • central nervous system,
  • lymphatic system,
  • pituitary gland,
  • brain stem nuclei,
  • the digestive tract,
  • reproductive system,
  • fat tissue,
  • lungs, liver, heart, muscles,
  • bladder,
  • in the nerve endings

In contrast, CB2 endocannabinoid receptors are mainly located in immune cells. When CB2 receptors activate, there is a fight against inflammation through appropriate stimulation of the immune system.



We know that CBD belongs to a group of phytokannabinoids. Scientists found that cannabis in its composition has a whole host of substances that can support the treatment of our body through the effect on the endocannabinoid system. Used in the right doses (the body of each person is different so everyone needs to find an individual dose for themselves), they can do a lot of good. I refer to our previous articles.

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